Diabetic neuropathy is a serious complication in 60 70 of diabetic patients involving both type 2 and type 1 several signaling pathways have been assumed to contribute to its development including increased activation of the polyol pathway oxidative stress advanced glycation end product age formation nerve hypoxia ischemia activation . Section i oxidative stress and diabetes chapter 1 oxidative stress and diabetic neuropathy abstract acknowledgments hyperglycemia as a crucial cause of diabetic neuropathy oxidative stress and diabetic neuropathy oxidative stress and antioxidant treatment in diabetic neuropathy. By blocking multiple pathway components figure figure1 1 multiple causes of oxidative stress would in turn be blocked preventing nervous system injury if coupled with additional antioxidant therapy or neurotrophic support this type of complication cocktail could provide the first effective treatment for diabetic neuropathy. Chapter 1 oxidative stress and diabetes induced vascular dysfunction role in diabetic neuropathy mark ek a or y m a orek y veterans affairs medical center university of iowa a city ia w io 52246 usa 1 oxidative stress and diabetes induced vascular dysfunction . Since the etiology of diabetic neuropathy is considered to have a large vascular component prevention of oxidative stress in diabetes is considered by many investigators to be a primary defense
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