Pregnancies complicated by type 1 diabetes exhibit higher oxidative stress and lower levels of antioxidant enzymes and vitamins when compared to pregnancies in non diabetic women antioxidant carotenoid deficiencies specifically of and carotenes in early gestation may be associated with later development of preeclampsia in type 1 diabetes. Diabetes oxidative stress and dietary antioxidants bridges the trans disciplinary divide among diabetologists endocrinologists and nutritionists in understanding and treating diabetes the book covers in a single volume the science of oxidative stress in diabetes and the potentially therapeutic use of natural antioxidants in the diet or food matrix. Oxidative stress in diabetes mellitus is there a role for hypoglycemic drugs and or antioxidants 219 peroxidase gpx halliwell 2011 sod maintains the cellular levels of o2 within the physiological concentrations by converting o 2 to h 2o 2 a more stable ros halliwell and gutteridge 2007 fukai and ushio fukai 2011. Cardiovascular complications characterized by endothelial dysfunction and accelerated atherosclerosis are the leading cause of morbidity and mortality associated with diabetes there is growing evidence that excess generation of highly reactive free radicals largely due to hyperglycemia causes oxidative stress which further exacerbates the development and progression of diabetes and its . Core tip oxidative stress is underling in the development of cardiovascular disease type 2 diabetes mellitus t2dm and diabetic complications increased oxidative stress appears to be a deleterious factor leading to insulin resistance dyslipidemia cell dysfunction impaired glucose tolerance and ultimately leading to t2dm
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